Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ABL2 | P42684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463543 | 0.93 | POLB (0.43) | POLBRAB9AKMT2AMEN1P4HB | |
| SCHEMBL7462825 | 0.91 | KMT2A (0.41) | POLBRAB9AKMT2AMEN1P4HB | |
| SCHEMBL7467832 | 0.89 | P4HB (0.47) | POLBRAB9AP4HBHSP90AA1 | |
| SCHEMBL7462648 | 0.84 | KMT2A (0.41) | POLBRAB9AKMT2AMEN1P4HB | |
| SCHEMBL7467645 | 0.83 | P4HB (0.41) | POLBRAB9AKMT2AMEN1P4HB | |
| SCHEMBL7465950 | 0.83 | AKR1C3 (0.39) | RAB9AKMT2AMEN1 | |
| SCHEMBL8831163 | 0.83 | P4HB (0.34) | POLBRAB9AKMT2AMEN1P4HB | |
| SCHEMBL8831002 | 0.83 | ABCB1 (0.33) | POLBRAB9AKMT2AMEN1P4HB | |
| SCHEMBL7458517 | 0.83 | P4HB (0.34) | POLBRAB9AKMT2AMEN1P4HB | |
| SCHEMBL7470343 | 0.82 | P4HB (0.47) | POLBRAB9AP4HBHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656360-B1 | TRIFLUOROMETHYLPYRROLOINDOLE CARBOXYLIC ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | KYORIN SEIYAKU KK (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-5629430-A | ANTICARCINOGENIC AGENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0656360-A1 | TRIFLUOROMETHYLPYRROLOINDOLE CARBOXYLIC ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |