Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.67 |
| ▸ | ABL1 | P00519 | 5/20 | 0.67 |
| ▸ | BCR | P11274 | 4/20 | 0.67 |
| ▸ | PRKCA | P17252 | 3/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.67 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.67 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463426 | 0.84 | ABL1 (0.80) | SRCABL1BCRPRKCAPDGFRB | |
| SCHEMBL7465915 | 0.81 | ABL1 (0.71) | SRCABL1BCRPRKCAPDGFRB | |
| SCHEMBL6256104 | 0.81 | ABL1 (1.00) | SRCABL1BCRPRKCAPDGFRB | |
| SCHEMBL8592858 | 0.80 | ABL1 (0.67) | SRCABL1BCRPRKCAPDGFRB | |
| SCHEMBL8554283 | 0.80 | ABL1 (0.69) | SRCABL1BCRPRKCAPDGFRB | |
| SCHEMBL8543865 | 0.78 | EGFR (0.70) | SRCABL1BCRPRKCAPRKCD | |
| SCHEMBL4902560 | 0.78 | ABL1 (0.72) | SRCABL1BCRPRKCAPDGFRB | |
| Hydrochloric Acid SCHEMBL8542078 | 0.77 | EGFR (0.69) | SRCABL1BCRPRKCAPRKCD | |
| Hydrochloric Acid SCHEMBL8542346 | 0.77 | EGFR (0.69) | SRCABL1BCRPRKCAPRKCD | |
| Bromide SCHEMBL8541076 | 0.77 | EGFR (0.69) | SRCABL1BCRPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0453731-B1 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1998-08-26 | — | — | EP | claimed |
| EP-0453731-A2 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1991-10-30 | — | — | EP | claimed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |