Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.69 |
| ▸ | BCR | P11274 | 6/20 | 0.69 |
| ▸ | SRC | P12931 | 4/20 | 0.69 |
| ▸ | PRKCA | P17252 | 3/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.69 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463426 | 0.83 | ABL1 (0.80) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL7465915 | 0.82 | ABL1 (0.71) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL6256104 | 0.81 | ABL1 (1.00) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL8592858 | 0.81 | ABL1 (0.67) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL7469128 | 0.80 | SRC (0.67) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL4902560 | 0.78 | ABL1 (0.72) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL7464447 | 0.77 | PIK3CA (0.62) | ABL1BCRSRCCAMK2DTLR8 | |
| SCHEMBL9843592 | 0.76 | CCNT1 (0.49) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL7832457 | 0.74 | ABL1 (0.45) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL4902208 | 0.74 | ABL1 (0.67) | ABL1BCRSRCPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0453731-B1 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1998-08-26 | — | — | EP | claimed |
| EP-0453731-B1 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1998-08-26 | — | — | EP | disclosed |
| US-5064963-A | CONTROLLING PH DURING REACTION | AMERICAN CYANAMID COMPANY (US) | 1991-11-12 | — | — | US | disclosed |