Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.71 |
| ▸ | BCR | P11274 | 2/20 | 0.71 |
| ▸ | PRKCA | P17252 | 2/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 1/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.71 |
| ▸ | SYK | P43405 | 16/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | CBFB | Q13951 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535971 | 0.88 | ABL1 (0.55) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL8592858 | 0.85 | ABL1 (0.67) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL7463426 | 0.85 | ABL1 (0.80) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL6256104 | 0.83 | ABL1 (1.00) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL8554283 | 0.82 | ABL1 (0.69) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL7469128 | 0.81 | SRC (0.67) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL4902560 | 0.80 | ABL1 (0.72) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL7535607 | 0.80 | SYK (0.54) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL21362368 | 0.76 | CYP3A4 (0.62) | ABL1BCRPRKCAPDGFRBSRC | |
| SCHEMBL7470857 | 0.76 | ABL1 (0.63) | ABL1BCRPRKCAPRKCDSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0453731-B1 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1998-08-26 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| EP-0453731-A2 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1991-10-30 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | claimed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0453731-B1 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1998-08-26 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5064963-A | CONTROLLING PH DURING REACTION | AMERICAN CYANAMID COMPANY (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0453731-A2 | Improved process for the synthesis of N-3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1991-10-30 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |