Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469291 | 1.00 | P4HTM (0.49) | P4HTMRAB9AHCAR2HDAC4HDAC3 | |
| SCHEMBL6231015 | 0.78 | CA12 (0.51) | RAB9AHCAR2CA12CA1CA2 | |
| SCHEMBL6231016 | 0.78 | CA12 (0.51) | RAB9AHCAR2CA12CA1CA2 | |
| SCHEMBL1124047 | 0.73 | P4HTM (0.55) | P4HTMRAB9AHCAR2HDAC4HDAC3 | |
| SCHEMBL4227326 | 0.73 | P4HTM (0.55) | P4HTMRAB9AHCAR2HDAC4HDAC3 | |
| SCHEMBL1093070 | 0.73 | P4HTM (0.55) | P4HTMRAB9AHCAR2HDAC4HDAC3 | |
| SCHEMBL4227332 | 0.73 | P4HTM (0.55) | P4HTMRAB9AHCAR2HDAC4HDAC3 | |
| SCHEMBL1093071 | 0.73 | P4HTM (0.55) | P4HTMRAB9AHCAR2HDAC4HDAC3 | |
| SCHEMBL1124046 | 0.73 | P4HTM (0.55) | P4HTMRAB9AHCAR2HDAC4HDAC3 | |
| SCHEMBL1714095 | 0.71 | HCAR3 (0.46) | P4HTMHCAR2HDAC4KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173424-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066566-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |