Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.70 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.58 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | BCR | P11274 | 2/20 | 0.52 |
| ▸ | PRKCA | P17252 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27822602 | 0.86 | CAMKK2 (0.63) | CAMKK2PIK3CGMAPK8EGFRCCNB2 | |
| SCHEMBL7461093 | 0.86 | PRKCA (0.69) | CAMKK2PIK3CGMAPK8EGFRCCNB2 | |
| SCHEMBL7461970 | 0.83 | PIK3CG (0.56) | CAMKK2PIK3CGMAPK8KDRABL1 | |
| SCHEMBL7471924 | 0.83 | ABL1 (0.54) | CAMKK2PIK3CGMAPK8EGFRABL1 | |
| SCHEMBL27116596 | 0.82 | PIK3CG (0.61) | CAMKK2PIK3CGMAPK8EGFRCCNB2 | |
| SCHEMBL7475168 | 0.82 | CCNB2 (0.55) | CAMKK2PIK3CGMAPK8EGFRCCNB2 | |
| SCHEMBL12801671 | 0.81 | CDK5 (0.66) | CAMKK2PIK3CGMAPK8EGFRCCNB2 | |
| SCHEMBL14569550 | 0.79 | EGFR (0.73) | CAMKK2PIK3CGMAPK8EGFRCCNB2 | |
| SCHEMBL12275292 | 0.78 | CAMKK2 (0.57) | CAMKK2PIK3CGMAPK8EGFRCCNB2 | |
| SCHEMBL7462149 | 0.78 | ABL1 (0.49) | CAMKK2PIK3CGMAPK8EGFRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |