Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263735 | 0.81 | KDM4E (0.46) | KCNH2TLR7 | |
| SCHEMBL9741847 | 0.78 | KDM4E (0.47) | ADORA3TLR7 | |
| SCHEMBL28075262 | 0.78 | KCNH2 (0.41) | KCNH2GPR84FFAR1FFAR4CYSLTR2 | |
| SCHEMBL28075142 | 0.78 | KCNH2 (0.41) | KCNH2GPR84FFAR1FFAR4CYSLTR2 | |
| SCHEMBL8639129 | 0.77 | KCNH2 (0.46) | KCNH2FAAHCES1 | |
| SCHEMBL15437934 | 0.74 | KCNH2 (0.44) | KCNH2FAAHCES1FFAR1FFAR4 | |
| SCHEMBL6371432 | 0.72 | KCNH2 (0.58) | KCNH2GPR84FFAR1FFAR4CYSLTR2 | |
| SCHEMBL5886568 | 0.72 | FFAR1 (0.51) | KCNH2GPR84FFAR1FFAR4MMP2 | |
| SCHEMBL29187197 | 0.72 | FFAR1 (0.51) | KCNH2GPR84FFAR1FFAR4MMP2 | |
| SCHEMBL5886652 | 0.71 | FFAR1 (0.63) | KCNH2GPR84FFAR1FFAR4MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817773-B1 | PYRIMIDINE COMPOUNDS | QINETIQ LTD (GB) | 2002-06-12 | — | — | EP | disclosed |
| US-6121448-A | LIQUID CRYSTALLINE COMPOUNDS | THE SECRETARY OF STATE FOR DEFENCE IN HER BRITTANIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) | 2000-09-19 | — | — | US | disclosed |
| US-5986096-A | REACTION OF HYDROGEN IODIDE WITH CHLORO-5-BROMOPYRIMIDINE | THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S A GOVERNMENT OF THE U.K. OF GT. BRITAIN & N. IRELAND OF DEFENCE EVALUATION & RESEARCH AGENCY (GB) | 1999-11-16 | — | — | US | disclosed |
| EP-0817773-A2 | PYRIMIDINE COMPOUNDS | THE SECRETARY OF STATE FOR DEFENCE (GB) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030344-A2 | PYRIMIDINE COMPOUNDS | THE SECRETARY OF STATE FOR DEFENCE (GB) | 1996-10-03 | — | — | WO | disclosed |