Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465337 | 0.90 | MAPT (0.39) | MAPTTP53HDAC1HDAC6SMN1; SMN2 | |
| Water SCHEMBL8593338 | 0.89 | MAPT (0.39) | MAPTTP53HDAC1HDAC6SMN1; SMN2 | |
| Water SCHEMBL8593336 | 0.89 | MAPT (0.39) | MAPTTP53HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL7465855 | 0.83 | SMN1; SMN2 (0.41) | MAPTTP53SMN1; SMN2THRBSCN9A | |
| SCHEMBL9222248 | 0.79 | GHSR (0.32) | MAPTTP53SMN1; SMN2GHSREPHX2 | |
| SCHEMBL7469133 | 0.78 | HDAC1 (0.49) | MAPTTP53HDAC1HDAC6ALDH1A1 | |
| SCHEMBL3235527 | 0.71 | GNRHR (0.39) | MAPTSMN1; SMN2ALDH1A1EPHX2NR1H4 | |
| SCHEMBL7470580 | 0.69 | PTGDR2 (0.48) | MAPTTP53HDAC1HDAC6SCN9A | |
| SCHEMBL3226270 | 0.69 | GNRHR (0.39) | MAPTSMN1; SMN2ALDH1A1EPHX2NR1H4 | |
| SCHEMBL8591950 | 0.69 | MAPT (0.38) | MAPTTP53SMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |
| WO-1995018105-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-07-06 | — | — | WO | disclosed |