Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.59 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475717 | 0.88 | CRHR1 (0.60) | CRHR1THRATHRB | |
| SCHEMBL6201091 | 0.86 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7477942 | 0.85 | CRHR1 (0.49) | CRHR1TP53MAPT | |
| SCHEMBL7482386 | 0.85 | CRHR1 (0.42) | CRHR1MAPT | |
| SCHEMBL7478515 | 0.84 | CRHR1 (0.50) | CRHR1TP53MAPT | |
| SCHEMBL6202927 | 0.83 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6200122 | 0.83 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL6203954 | 0.82 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL6203563 | 0.82 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL7474501 | 0.82 | CRHR1 (0.59) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |