Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.59 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5417192 | 0.84 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL7474054 | 0.83 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL7470192 | 0.82 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL5419752 | 0.82 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL7477918 | 0.82 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL7478531 | 0.82 | TLR8 (0.44) | CRHR1NPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5414805 | 0.81 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL6204821 | 0.81 | CRHR1 (0.58) | CRHR1 | |
| SCHEMBL5418485 | 0.80 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL5417184 | 0.80 | CRHR1 (0.62) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |