Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481164 | 0.87 | MAPT (0.38) | KDM4EMAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL7467207 | 0.82 | AKR1B1 (0.33) | ALDH1A1KMT2AMEN1SMN1; SMN2KCNE1 | |
| Hydrochloric Acid SCHEMBL8525004 | 0.78 | MEN1 (0.31) | KMT2AMEN1 | |
| SCHEMBL8481824 | 0.77 | KCNE1 (0.40) | KDM4EATMMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7478336 | 0.75 | MEN1 (0.36) | MAPTALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8481162 | 0.75 | ALDH1A1 (0.35) | KDM4EATMMAPK1MAPTALDH1A1 | |
| SCHEMBL7471976 | 0.74 | KCNE1 (0.33) | KMT2AMEN1KCNE1KCNQ1CYP1A2 | |
| SCHEMBL8476685 | 0.73 | KCNE1 (0.53) | MAPTALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8481451 | 0.71 | KCNE1 (0.49) | KDM4EMAPTALDH1A1KCNE1KCNQ1 | |
| SCHEMBL7471057 | 0.70 | KCNE1 (0.46) | MAPTALDH1A1KMT2AMEN1KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |