Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.74 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.69 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.69 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.69 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3792617 | 0.87 | KMT2A (0.58) | MEN1KMT2ARAB9APDK1PDK2 | |
| SCHEMBL8401386 | 0.86 | PDK1 (0.66) | MEN1KMT2ARAB9APDK1PDK2 | |
| SCHEMBL31718129 | 0.86 | PDK1 (0.69) | MEN1KMT2ARAB9APDK1PDK2 | |
| SCHEMBL14254880 | 0.86 | PDK1 (0.69) | MEN1KMT2ARAB9APDK1PDK2 | |
| SCHEMBL3810058 | 0.84 | MAPT (0.60) | MEN1KMT2ARAB9APDK1PDK2 | |
| SCHEMBL12900892 | 0.84 | PDK1 (0.70) | MEN1KMT2ARAB9APDK1PDK2 | |
| SCHEMBL4567645 | 0.83 | KMT2A (0.55) | MEN1KMT2ARAB9APDK1PDK2 | |
| SCHEMBL6351013 | 0.82 | PDK1 (0.65) | MEN1KMT2ARAB9APDK1PDK2 | |
| SCHEMBL1307490 | 0.81 | KDM4E (0.63) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL18088737 | 0.81 | POLB (0.58) | MEN1KMT2ARAB9APDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| EP-0636622-B1 | Isoxazole derivatives and their use as herbicides | AVENTIS AGRICULTURE LTD (GB) | 2002-10-23 | — | — | EP | disclosed |
| EP-1160244-A1 | Isoxazole derivatives and their use as herbicides | RHONE-POULENC AGRICULTURE LIMITED (GB) | 2001-12-05 | — | — | EP | disclosed |
| US-5489570-A | PRE- OR POST-EMERGENCE | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1996-02-06 | — | — | US | disclosed |
| WO-1995025105-A1 | ISOXAZOLE DERIVATIVES AND THEIR USE AS HERBICIDES | RHONE-POULENC AGRICULTURE LTD (GB) | 1995-09-21 | — | — | WO | disclosed |
| WO-1995025099-A1 | 2-CYANO-1,3-DIONE DERIVATIVES USEFUL AS HERBICIDES | RHONE-POULENC AGRICULTURE LTD. (GB) | 1995-09-21 | — | — | WO | disclosed |
| EP-0636622-A1 | Isoxazole derivatives and their use as herbicides | RHONE POULENC AGRICULTURE LTD. (GB) | 1995-02-01 | — | — | EP | disclosed |
| US-4680301-A | 6-isothiocyanato-2,5-substituted benzothiazoles or benzoxazoles useful as anthelmintic effective agents | CIBA-GEIGY CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0175650-A2 | Benzazoles, process for their preparation, pharmaceutical compositions containing them and their use | CIBA-GEIGY AG (CH) | 1986-03-26 | — | — | EP | disclosed |