Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224039 | 0.85 | KDM4E (0.54) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL3792617 | 0.84 | KMT2A (0.58) | KMT2AMEN1RAB9APDK1PDK2 | |
| SCHEMBL7470294 | 0.83 | MEN1 (0.74) | KMT2AMEN1RAB9APDK1PDK2 | |
| SCHEMBL31718129 | 0.79 | PDK1 (0.69) | KMT2AMEN1RAB9APDK1PDK2 | |
| SCHEMBL14254880 | 0.79 | PDK1 (0.69) | KMT2AMEN1RAB9APDK1PDK2 | |
| SCHEMBL1307490 | 0.79 | KDM4E (0.63) | KMT2AMEN1RAB9AKDM4EALDH1A1 | |
| SCHEMBL18088737 | 0.78 | POLB (0.58) | KMT2AMEN1RAB9APDK1PDK2 | |
| SCHEMBL2212062 | 0.78 | KMT2A (0.52) | KMT2AMEN1RAB9APDK1PDK2 | |
| SCHEMBL2212088 | 0.78 | KMT2A (0.52) | KMT2AMEN1RAB9APDK1PDK2 | |
| SCHEMBL16992886 | 0.77 | RAB9A (0.51) | KMT2AMEN1RAB9APDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045414-B2 | Pyrrolidin-2-ones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-06-02 | — | — | US | disclosed |
| US-9045414-B2 | Pyrrolidin-2-ones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-06-02 | — | — | US | disclosed |
| US-20120122839-A1 | NOVEL PYRROLIDIN-2-ONES | PRIAXON AG (DE) | 2012-05-17 | — | — | US | disclosed |
| US-8119623-B2 | Pyrrolidin-2-ones | PRIAXON AG (DE) | 2012-02-21 | — | — | US | disclosed |
| US-20100075949-A1 | NOVEL PYRROLIDIN-2-ONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075949-A1 | NOVEL PYRROLIDIN-2-ONES | ING2, HMGB2, API5 | KMT2A 2222/4885MEN1 1975/4885RAB9A 3032/4885 |
| US-20120122839-A1 | NOVEL PYRROLIDIN-2-ONES | ING2, HMGB2, API5 | KMT2A 2222/4885MEN1 1975/4885RAB9A 3032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.