Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.64 |
| ▸ | NAMPT | P43490 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557279 | 0.78 | ROCK1 (1.00) | ROCK1ROCK2 | |
| SCHEMBL26546719 | 0.76 | RAB9A (0.73) | NAMPTRAB9APOLBALDH1A1NPC1 | |
| SCHEMBL20379743 | 0.75 | NAMPT (1.00) | ROCK1ROCK2NAMPTALOX5 | |
| SCHEMBL4743979 | 0.75 | ROCK1 (0.87) | ROCK1ROCK2ALDH1A1ALOX5LMNA | |
| SCHEMBL128793 | 0.75 | ALDH1A1 (1.00) | RAB9APOLBALDH1A1ALOX5NPC1 | |
| Iodide SCHEMBL6959702 | 0.73 | ALDH1A1 (0.96) | RAB9APOLBALDH1A1ALOX5NPC1 | |
| SCHEMBL16946645 | 0.73 | NPC1 (0.84) | NAMPTRAB9APOLBALDH1A1NPC1 | |
| SCHEMBL11615956 | 0.73 | NAMPT (0.84) | ROCK1ROCK2NAMPTRAB9APOLB | |
| SCHEMBL126387 | 0.73 | KMT2A (0.66) | RAB9APOLBALDH1A1NPC1LMNA | |
| SCHEMBL7463271 | 0.73 | RAB9A (0.60) | NAMPTRAB9APOLBALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871619-B1 | PHENYL THIAZOLE DERIVATIVES WITH ANTI HERPES VIRUS PROPERTIES | BOEHRINGER INGELHEIM PHARMA (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6057451-A | AMINOTHIAZOLE DERIVATIVES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-05-02 | — | — | US | disclosed |