Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | GRN | P28799 | 1/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4328573 | 0.86 | SLC6A4 (0.55) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL6469200 | 0.84 | GRN (0.54) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL10383881 | 0.84 | SLC6A4 (0.53) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL8082304 | 0.84 | SLC6A4 (0.59) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL2175542 | 0.82 | SMN1; SMN2 (0.48) | SLC6A2CYP2C19CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL10555661 | 0.81 | SLC6A2 (0.55) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL8169646 | 0.81 | SLC6A4 (0.50) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL11569485 | 0.81 | ALDH1A1 (0.44) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| Ammonia Solution, Strong SCHEMBL27747945 | 0.80 | SMN1; SMN2 (0.47) | SLC6A2CYP2C19CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL6469058 | 0.79 | GRN (0.50) | SLC6A4SLC6A2HTR2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054886-B1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS, IN PARTICULAR AS UROKINASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2002-09-04 | — | — | EP | disclosed |
| US-4151303-A | Phenoxyalkylcarboxylic acid compounds and serum-lipid and triglyceride depressing therapeutic compositions | BOEHRINGER MANNHEIM GMBH (DE) | 1979-04-24 | — | — | US | disclosed |