SCHEMBL7470567

SCHEMBL7470567

CCON=C(C(C)=NOCc1ccccc1C(=COC)C(=O)OC)c1ccc(Oc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 3/20 0.38
MAPK14 Q16539 2/20 0.38
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
S1PR1 P21453 1/20 0.32
MAOB P27338 2/20 0.32
RXFP1 Q9HBX9 1/20 0.32
CYP1A1 P04798 1/20 0.32
CYP1B1 Q16678 1/20 0.32
PTPN1 P18031 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7470560 1.00 HIF1A (0.38) HIF1AMAPK14MEN1KMT2AS1PR1
SCHEMBL7467255 0.93 HIF1A (0.41) HIF1AMAPK14RXFP1PTPN1
SCHEMBL7467258 0.93 HIF1A (0.41) HIF1AMAPK14RXFP1PTPN1
SCHEMBL7741768 0.93 HIF1A (0.34) HIF1AMEN1KMT2A
SCHEMBL7465129 0.92 MAOB (0.43) HIF1AMAOB
SCHEMBL7465132 0.92 MAOB (0.43) HIF1AMAOB
SCHEMBL7463027 0.90 HIF1A (0.40) HIF1A
SCHEMBL7463026 0.90 HIF1A (0.40) HIF1A
SCHEMBL7469583 0.89 HIF1A (0.35) HIF1A
SCHEMBL7469587 0.89 HIF1A (0.35) HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865424-B1 PESTICIDES BAYER AG (DE) 2002-09-18 EP disclosed