Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.59 |
| ▸ | SLC16A3 | O15427 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
| ▸ | BID | P55957 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047296 | 0.94 | FOLH1 (0.61) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL729909 | 0.90 | FOLH1 (0.70) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL9345842 | 0.88 | FOLH1 (0.68) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL5734483 | 0.86 | FOLH1 (0.66) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL31474045 | 0.86 | FOLH1 (0.70) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL7182402 | 0.84 | AKR1C3 (0.47) | FOLH1SLC16A3ALDH1A1TSHR | |
| SCHEMBL7460853 | 0.84 | KDM4E (0.42) | FOLH1SLC16A3ALDH1A1TSHRDHODH | |
| SCHEMBL11710027 | 0.83 | FOLH1 (0.61) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL4907779 | 0.83 | FOLH1 (0.61) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL7185403 | 0.83 | AKR1C3 (0.46) | FOLH1SLC16A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650476-B1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMA CO LTD (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6136826-A | AMINOPIPERIDINE COMPOUNDS SUBSTITUTED WITH ALKANOYL | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| CN-1052224-C | Peripheral Vasodilating agent containing N-acylated 4-amino piperidine derivatives as active ingredients | OTSUKA PHARMA CO LTD (JP) | 2000-05-10 | — | — | CN | disclosed |
| US-5760058-A | Peripheral vasodilating agent containing piperidine derivative as active ingredient | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-02 | — | — | US | disclosed |
| US-5656642-A | Peripheral vasodilating agent containing piperidine derivative as active ingredient | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| EP-0650476-A1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994022826-A1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |