Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.61 |
| ▸ | BID | P55957 | 1/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | SLC16A3 | O15427 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162476 | 0.96 | FOLH1 (0.61) | FOLH1BIDBCL2L1MCL1BAK1 | |
| SCHEMBL729909 | 0.92 | FOLH1 (0.70) | FOLH1BIDBCL2L1MCL1BAK1 | |
| SCHEMBL9345842 | 0.90 | FOLH1 (0.68) | FOLH1BIDBCL2L1MCL1BAK1 | |
| SCHEMBL10641089 | 0.90 | TSHR (0.68) | FOLH1MAPTSLC16A3ALDH1A1TSHR | |
| SCHEMBL8698803 | 0.89 | FOLH1 (0.58) | FOLH1BIDBCL2L1MCL1BAK1 | |
| SCHEMBL29975597 | 0.88 | FOLH1 (0.66) | FOLH1MAPTSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL166927 | 0.88 | FOLH1 (0.66) | FOLH1MAPTSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL31474045 | 0.88 | FOLH1 (0.70) | FOLH1SLC16A3SMN1; SMN2ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL7699238 | 0.86 | FOLH1 (0.63) | FOLH1MAPTSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL8702953 | 0.86 | FOLH1 (0.63) | FOLH1MAPTSMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4054579-A | Intermediates in the process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids | SYNTEX (U.S.A.) INC. (US) | 1977-10-18 | — | — | US | disclosed |
| US-4011243-A | Intermediate in the oxidative process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids | SYNTEX (U.S.A.) INC. (US) | 1977-03-08 | — | — | US | disclosed |
| US-3979430-A | Solvolytic process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids | SYNTEX (U.S.A.) INC. (US) | 1976-09-07 | — | — | US | disclosed |