Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.61 |
| ▸ | SLC16A3 | O15427 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470589 | 0.94 | FOLH1 (0.59) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL5734483 | 0.88 | FOLH1 (0.66) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL729909 | 0.88 | FOLH1 (0.70) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL31474045 | 0.88 | FOLH1 (0.70) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL9345842 | 0.86 | FOLH1 (0.68) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL7178647 | 0.84 | AKR1C3 (0.48) | FOLH1ALDH1A1TSHR | |
| Ethylene SCHEMBL18893737 | 0.84 | FOLH1 (0.70) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL30365583 | 0.83 | FOLH1 (0.76) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL70392 | 0.83 | FOLH1 (0.76) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL7498472 | 0.83 | LMNA (0.44) | FOLH1SLC16A3ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| EP-0180188-A2 | A composition for increasing the anti-cancer activity of an anti-cancer compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |