Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732696 | 0.84 | DDAH1 (0.58) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL7160207 | 0.84 | DDAH1 (0.58) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL29642026 | 0.83 | DDAH1 (0.61) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL14361902 | 0.83 | DDAH1 (0.61) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL8017570 | 0.80 | ALDH1A1 (0.57) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL11498671 | 0.79 | ALDH1A1 (0.58) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL761148 | 0.77 | CHRM1 (0.71) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL10892813 | 0.77 | GAA (0.59) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL7435327 | 0.76 | DDAH1 (0.56) | RAB9ANPC1DDAH1POLBSMN1; SMN2 | |
| SCHEMBL10337354 | 0.76 | ALDH1A1 (0.68) | RAB9ANPC1DDAH1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449682-A | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5240938-A | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0543491-A2 | Angiotensin II antagonists having a substituted 1,3-benzodioxolering or 1,3-benzodithiolering | MERCK & CO. INC. (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5187159-A | Hypotensive agents, psychological disorders | MERCK & CO., INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5177074-A | Heterocyclic nitrogen compounds used to treat hypertension, cognitive dysfunction, anxiety or depression | MERCK & CO., INC. (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0513979-A1 | Angiotensin II antagonists incorporating a substituted thiophene or furan | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0510813-A1 | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | disclosed |
| EP-0508723-A1 | Angiotensin II antagonists incorporating an indole or dihydroindole | MERCK & CO. INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5151435-A | Hypotensive agents, glaucoma and cognition activators | MERCK & CO., INC. (US) | 1992-09-29 | — | — | US | disclosed |
| US-5128327-A | Hypotensive agents; congestive heart failure; antidepressants; anxiolytic agents; cognition activators | MERCK & CO., INC. (US) | 1992-07-07 | — | — | US | disclosed |
| WO-1991011999-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| EP-0400835-A1 | Substituted benzimidazoles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |