Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.30 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804409 | 0.74 | NT5E (0.44) | GRM5CDK8ERN1 | |
| SCHEMBL31074157 | 0.66 | ERN1 (0.49) | ERN1 | |
| SCHEMBL612923 | 0.66 | ERN1 (0.49) | ERN1 | |
| SCHEMBL13746042 | 0.61 | CDK8 (0.69) | CDK8 | |
| SCHEMBL2212554 | 0.60 | ERN1 (0.41) | ERN1PIK3CA | |
| SCHEMBL5711323 | 0.57 | LMNA (0.57) | GRM5ERN1 | |
| SCHEMBL4305451 | 0.57 | MAOA (0.50) | GRM5 | |
| SCHEMBL3679602 | 0.57 | LMNA (0.43) | GRM5ERN1 | |
| SCHEMBL2561391 | 0.57 | FEN1 (0.47) | — | |
| SCHEMBL19154057 | 0.57 | MEN1 (0.46) | GRM5ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214319-A1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | Merck Sharp & Dohme Limited (GB) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018000-A1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-15 | — | — | WO | disclosed |