Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 10/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467847 | 0.83 | GRIA4 (0.51) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL7468611 | 0.82 | GRIA2 (0.42) | GRIA4GRIA2GRIA1GRIA3NPY5R | |
| SCHEMBL7474718 | 0.81 | GRIA4 (0.53) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL7473863 | 0.81 | GRIA2 (0.42) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL7467018 | 0.80 | GRIA2 (0.62) | GRIA4GRIA2GRIA1GRIA3NPY5R | |
| SCHEMBL7478378 | 0.80 | GRIA2 (0.41) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL7475999 | 0.77 | GRIA1 (0.38) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL7477103 | 0.75 | GRIA2 (0.40) | GRIA4GRIA2GRIA1GRIA3NPY5R | |
| SCHEMBL7470281 | 0.72 | NPY5R (0.38) | GRIA4GRIA2GRIA1GRIA3NPY5R | |
| SCHEMBL7474813 | 0.72 | GRIA2 (0.46) | GRIA4GRIA2GRIA1GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |