Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477103 | 0.90 | GRIA2 (0.40) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7478378 | 0.79 | GRIA2 (0.41) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7473870 | 0.76 | NPY5R (0.38) | NPY5RGRIA2PKMGRIA1GRIA3 | |
| SCHEMBL7475999 | 0.76 | GRIA1 (0.38) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7470882 | 0.72 | GRIA4 (0.50) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7468611 | 0.72 | GRIA2 (0.42) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7473863 | 0.71 | GRIA2 (0.42) | GRIA2GRIA1GRIA3F2GRIA4 | |
| SCHEMBL7467018 | 0.70 | GRIA2 (0.62) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7474813 | 0.69 | GRIA2 (0.46) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL8611621 | 0.69 | PKM (0.36) | PKMKDM4ENPC1GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |