SCHEMBL7470898

SCHEMBL7470898

CC(C)(ON1C(C)(C)CC(OC(=O)CCCCCCCCC(=O)OC2CC(C)(C)N(OC(C)(C)c3ccccc3)C(C)(C)C2)CC1(C)C)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.46
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
TSHR P16473 3/20 0.44
MAPT P10636 2/20 0.37
ALDH1A1 P00352 2/20 0.36
ESR1 P03372 1/20 0.36
HSD17B10 Q99714 1/20 0.36
NAAA Q02083 2/20 0.35
KDM4E B2RXH2 1/20 0.34
CYP3A4 P08684 1/20 0.34
HTT P42858 1/20 0.34
CYP2D6 P10635 1/20 0.34
CHRM3 P20309 1/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1233022 0.85 GAA (0.44) GAAKMT2AMEN1TSHRMAPT
SCHEMBL1232053 0.84 GAA (0.44) GAAKMT2AMEN1TSHRMAPT
SCHEMBL12544321 0.84 TSHR (0.62) GAAKMT2AMEN1TSHRALDH1A1
SCHEMBL7475549 0.82 NAAA (0.42) GAAKMT2AMEN1TSHRALDH1A1
SCHEMBL7029903 0.81 KMT2A (0.48) GAAKMT2AMEN1TSHRMAPT
SCHEMBL10464829 0.81 TSHR (0.67) GAAKMT2AMEN1TSHRMAPT
SCHEMBL27657095 0.81 GAA (0.42) GAAKMT2AMEN1TSHRMAPT
SCHEMBL10467538 0.81 TSHR (0.52) GAAKMT2AMEN1TSHRALDH1A1
SCHEMBL7473740 0.80 KMT2A (0.45) GAAKMT2AMEN1TSHRALDH1A1
SCHEMBL698553 0.80 KMT2A (0.47) GAAKMT2AMEN1TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0309402-B2 N-substituted hindered amine stabilizers CIBA SC HOLDING AG (CH) 2002-06-12 EP disclosed
EP-0309402-B1 N-substituted hindered amine stabilizers CIBA GEIGY AG (CH) 1995-01-11 EP disclosed
US-5204473-A O-substituted N-hydroxy hindered amine stabilizers CIBA-GEIGY CORPORATION (US) 1993-04-20 US disclosed
US-4921962-A REACTION OF AMINE WITH HYDROPEROXIDE CIBA-GEIGY CORPORATION (US) 1990-05-01 US disclosed
EP-0309402-A1 N-substituted hindered amine stabilizers CIBA-GEIGY AG (CH) 1989-03-29 EP disclosed