Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 17/20 | 0.42 |
| ▸ | CTSS | P25774 | 17/20 | 0.42 |
| ▸ | CTSK | P43235 | 17/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590847 | 0.90 | CTSL (0.40) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL6475733 | 0.85 | CTSL (0.41) | CTSLCTSSCTSK | |
| SCHEMBL6590657 | 0.83 | CYP2C19 (0.39) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL6589413 | 0.79 | CHRM2 (0.33) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL6590154 | 0.78 | CYP2C19 (0.34) | CTSLCTSSCTSKCYP2C19HIF1A | |
| SCHEMBL6093210 | 0.74 | CTSL (0.41) | CTSLCTSSCTSK | |
| SCHEMBL6476626 | 0.74 | ESRRG (0.34) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL6483017 | 0.73 | ACHE (0.35) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL6590839 | 0.73 | CTSL (0.39) | KMT2ACTSLCTSSCTSKMAPT | |
| SCHEMBL7411727 | 0.73 | CTSL (0.39) | KMT2ACTSLCTSSCTSKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002544274-A | — | — | 2002-12-24 | — | — | JP | claimed |
| EP-1178986-A2 | FURANONE DERIVATIVES AS INHIBITORS OF CATHEPSIN S | Medivir UK Ltd (GB) | 2002-02-13 | — | — | EP | claimed |
| WO-2000069855-A2 | FURANONE DERIVATIVES AS INHIBITORS OF CATHEPSIN S | MEDIVIR UK LIMITED (GB) | 2000-11-23 | — | — | WO | claimed |