Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ESRRG | P62508 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745473 | 0.93 | KMT2A (0.44) | SLC13A5KMT2AESRRGRCE1MEN1 | |
| SCHEMBL748461 | 0.92 | ESRRG (0.46) | SLC13A5KMT2AESRRGHDAC6RCE1 | |
| SCHEMBL747114 | 0.91 | C5AR1 (0.41) | SLC13A5KMT2AESRRGRCE1MEN1 | |
| SCHEMBL746610 | 0.91 | TP53 (0.42) | SLC13A5KMT2AESRRGRCE1MEN1 | |
| SCHEMBL748509 | 0.89 | LPAR1 (0.43) | SLC13A5KMT2AESRRGMEN1LMNA | |
| SCHEMBL748533 | 0.89 | ESRRG (0.37) | SLC13A5KMT2AESRRGLMNATP53 | |
| SCHEMBL749104 | 0.87 | SLC13A5 (0.35) | SLC13A5KMT2AESRRGMEN1TP53 | |
| SCHEMBL748780 | 0.87 | TP53 (0.35) | SLC13A5KMT2AESRRGMEN1CRHBP | |
| SCHEMBL747162 | 0.87 | TACR1 (0.37) | SLC13A5KMT2AHDAC6HDAC8TP53 | |
| SCHEMBL748523 | 0.87 | LPAR1 (0.38) | SLC13A5KMT2ACRHBPCRHR2C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |