Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 11/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL746610 | 0.89 | TP53 (0.42) | SLC13A5KMT2ATP53MAPT | |
| SCHEMBL745473 | 0.88 | KMT2A (0.44) | SLC13A5OPRM1OPRD1KMT2AMAPT | |
| SCHEMBL748780 | 0.88 | TP53 (0.35) | SLC13A5KMT2ATP53MAPT | |
| SCHEMBL750565 | 0.88 | TACR1 (0.40) | TACR1SLC13A5 | |
| SCHEMBL748461 | 0.88 | ESRRG (0.46) | SLC13A5HDAC6KMT2ATP53MAPT | |
| SCHEMBL747114 | 0.87 | C5AR1 (0.41) | SLC13A5OPRM1OPRD1KMT2A | |
| SCHEMBL747130 | 0.87 | SLC13A5 (0.37) | SLC13A5HDAC8HDAC6KMT2ATP53 | |
| SCHEMBL748523 | 0.86 | LPAR1 (0.38) | SLC13A5OPRM1OPRD1KMT2A | |
| SCHEMBL745501 | 0.86 | TMEM97 (0.39) | SLC13A5OPRM1OPRD1KMT2ATP53 | |
| SCHEMBL748724 | 0.86 | F10 (0.40) | SLC13A5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |