Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 7/20 | 0.47 |
| ▸ | FLT3 | P36888 | 6/20 | 0.47 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | AXL | P30530 | 3/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10974957 | 0.83 | JAK2 (0.53) | MEN1KMT2AJAK2JAK3JAK1 | |
| SCHEMBL7216465 | 0.81 | PTGS2 (0.54) | MEN1KMT2AJAK2TYK2NPC1 | |
| SCHEMBL4562555 | 0.78 | JAK2 (0.59) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL7465536 | 0.77 | ABL1 (0.54) | MEN1KMT2AJAK2JAK3NPC1 | |
| SCHEMBL4559669 | 0.75 | JAK1 (0.59) | JAK2JAK3JAK1TYK2AXL | |
| SCHEMBL27955749 | 0.73 | AURKA (0.49) | — | |
| SCHEMBL11478969 | 0.71 | RAB9A (0.65) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6034237 | 0.71 | KDR (0.76) | RAB9A | |
| SCHEMBL2448957 | 0.69 | SYK (0.59) | JAK3JAK1NPC1RAB9ASTK17B | |
| SCHEMBL7475710 | 0.68 | ABL1 (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |