Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27110837 | 0.95 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL7562459 | 0.91 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL1021995 | 0.90 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL9211588 | 0.88 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL2056324 | 0.88 | RAB9A (0.54) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL13387551 | 0.88 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL7562461 | 0.88 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL2056321 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL13073361 | 0.87 | RAB9A (0.56) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL11338386 | 0.86 | RAB9A (0.57) | SMN1; SMN2ALDH1A1MAPK1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650476-B1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMA CO LTD (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6136826-A | AMINOPIPERIDINE COMPOUNDS SUBSTITUTED WITH ALKANOYL | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| US-5760058-A | Peripheral vasodilating agent containing piperidine derivative as active ingredient | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-02 | — | — | US | disclosed |
| US-5656642-A | Peripheral vasodilating agent containing piperidine derivative as active ingredient | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| WO-1994022826-A1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |