SCHEMBL7472499

SCHEMBL7472499

CCC(CC)NC(=O)N(C)c1ccc(COc2cc(F)cc(C3(OC)CCOCC3)c2)cc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 20/20 0.55
PTGS1 P23219 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7483194 0.92 ALOX5 (0.54) ALOX5PTGS1
SCHEMBL7477587 0.91 ALOX5 (0.57) ALOX5PTGS1
SCHEMBL7534093 0.90 ALOX5 (0.55) ALOX5PTGS1
SCHEMBL7468853 0.89 ALOX5 (0.60) ALOX5
SCHEMBL7534448 0.89 ALOX5 (0.59) ALOX5
SCHEMBL7484790 0.88 ALOX5 (0.56) ALOX5PTGS1
SCHEMBL7483140 0.88 ALOX5 (0.54) ALOX5PTGS1
SCHEMBL7480784 0.88 ALOX5 (0.55) ALOX5PTGS1
SCHEMBL7478747 0.87 ALOX5 (0.56) ALOX5
SCHEMBL7476590 0.87 ALOX5 (0.58) ALOX5PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1250332-A1 INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION Abbott Laboratories (US) 2002-10-23 EP claimed
WO-2001044223-A1 INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION ABBOTT LABORATORIES (US) 2001-06-21 WO claimed
EP-1250332-A1 INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION Abbott Laboratories (US) 2002-10-23 EP disclosed
WO-2001044223-A1 INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION ABBOTT LABORATORIES (US) 2001-06-21 WO disclosed