Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3504485 | 0.78 | PDE3B (0.56) | HPGDALDH1A1KDM4EGALR3GAA | |
| SCHEMBL2320354 | 0.75 | AHR (0.41) | HPGDKDM4EGAAPDE3BPDE3A | |
| SCHEMBL9188011 | 0.75 | NPC1 (0.48) | HPGDALDH1A1KDM4EGALR3GAA | |
| SCHEMBL14154838 | 0.75 | ALK (0.44) | ALDH1A1KDM4EGAAPDE3BPDE3A | |
| SCHEMBL4921058 | 0.75 | ALDH1A1 (0.45) | HPGDALDH1A1KDM4EGALR3GAA | |
| SCHEMBL9382851 | 0.72 | ABL1 (0.47) | HPGDALDH1A1KDM4ECYP2C19 | |
| SCHEMBL10890730 | 0.71 | GAA (0.43) | GAAPDE3BPDE3APDE4APDE4B | |
| SCHEMBL6196824 | 0.68 | NQO1 (0.48) | HPGDALDH1A1KDM4EGAALMNA | |
| SCHEMBL5270008 | 0.66 | ALK (0.56) | ALDH1A1CYP2C19AURKBCDK8JAK2 | |
| SCHEMBL17183457 | 0.65 | L3MBTL1 (0.66) | KDM4EGAALMNACYP2C19AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | claimed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | claimed |
| US-6174922-B1 | FOR POTENTIATING GLUTAMATE RECEPTOR FUNCTION IN WARM BLOODED MAMMAL | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | claimed |
| WO-1999043285-A2 | SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1999-09-02 | — | — | WO | claimed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | claimed |
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6174922-B1 | FOR POTENTIATING GLUTAMATE RECEPTOR FUNCTION IN WARM BLOODED MAMMAL | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |