Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 5/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6248780 | 0.87 | LTA4H (0.51) | HDAC8CA12CA1CA2CA9 | |
| SCHEMBL25367299 | 0.86 | L3MBTL1 (0.56) | HDAC8L3MBTL1 | |
| SCHEMBL6439701 | 0.84 | PPARA (0.54) | HDAC8L3MBTL1GAA | |
| SCHEMBL25363631 | 0.84 | POLB (0.54) | HDAC8GAA | |
| SCHEMBL25362868 | 0.84 | SMN1; SMN2 (0.49) | HDAC8CA12CA1CA2CA9 | |
| SCHEMBL16673260 | 0.84 | L3MBTL1 (0.52) | TDP1TSHRL3MBTL1 | |
| SCHEMBL21017964 | 0.84 | HDAC8 (0.43) | HDAC8CA12CA1CA2CA9 | |
| SCHEMBL31522349 | 0.83 | KMT2A (0.47) | HDAC8GAA | |
| SCHEMBL18720317 | 0.83 | PLA2G4B (0.57) | TDP1TSHRL3MBTL1 | |
| SCHEMBL3170185 | 0.83 | HDAC8 (0.43) | HDAC8CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |