SCHEMBL7472872

SCHEMBL7472872

COC(CNC(=O)N(N=Cc1ccccc1)c1cc(Cl)c(Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c(Cl)c1)OC

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.34
MEN1 O00255 5/20 0.34
POLB P06746 1/20 0.34
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.32
LMNA P02545 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MAPK8 P45983 1/20 0.32
MAPK9 P45984 1/20 0.32
PPARG P37231 2/20 0.31
PPARD Q03181 1/20 0.31
PPARA Q07869 1/20 0.31
DRD2 P14416 1/20 0.31
TBXA2R P21731 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8005624 0.93 SRD5A2 (0.36) KMT2AMEN1POLBKDM4EALDH1A1
SCHEMBL8005622 0.93 SRD5A2 (0.36) KMT2AMEN1POLBKDM4EALDH1A1
SCHEMBL7830131 0.92 LMNA (0.35) KMT2AMEN1KDM4EALDH1A1GAA
SCHEMBL8000238 0.91 LMNA (0.34) KMT2AMEN1POLBKDM4EALDH1A1
SCHEMBL7829241 0.87 KMT2A (0.36) KMT2AMEN1POLBKDM4EALDH1A1
SCHEMBL7829244 0.87 KMT2A (0.36) KMT2AMEN1POLBKDM4EALDH1A1
SCHEMBL8002325 0.86 KDM4E (0.33) KMT2AMEN1KDM4EALDH1A1GAA
SCHEMBL8001911 0.86 LMNA (0.32) KMT2AMEN1KDM4EALDH1A1LMNA
SCHEMBL8001906 0.86 LMNA (0.32) KMT2AMEN1KDM4EALDH1A1LMNA
SCHEMBL7839893 0.85 MRGPRX4 (0.34) KMT2AMEN1KDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0831088-B1 1,2,4-Triazine-3,5-dione derivatives as anticoccidial agents TAKEDA SCHERING PLOUGH ANIMAL (JP) 2002-11-27 EP disclosed
US-5985875-A USEFUL AS ANTI-PROTOZOAL AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-11-16 US disclosed
EP-0831088-A1 1,2,4-Triazine-3,5-dione derivatives as anticoccidial agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-25 EP disclosed