Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.72 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.56 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 5/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.56 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | ELANE | P08246 | 2/20 | 0.49 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30583450 | 0.84 | PDE4D (1.00) | PDE4BPDE4DSLC5A1SLC5A2MEN1 | |
| SCHEMBL2201643 | 0.84 | PDE4D (1.00) | PDE4BPDE4DSLC5A1SLC5A2MEN1 | |
| SCHEMBL7465575 | 0.83 | ALDH1A1 (0.51) | PDE4BPDE4DKMT2AELANESMN1; SMN2 | |
| SCHEMBL10317229 | 0.81 | PDE4B (0.68) | PDE4BPDE4DSLC5A1SLC5A2MEN1 | |
| SCHEMBL537273 | 0.81 | PDE4B (0.67) | PDE4BPDE4DSLC5A1SLC5A2MEN1 | |
| SCHEMBL3146601 | 0.81 | PDE4B (0.67) | PDE4BPDE4DSLC5A1SLC5A2MEN1 | |
| SCHEMBL7471831 | 0.80 | PDE4D (0.66) | PDE4DMEN1ALOX12KMT2ASMN1; SMN2 | |
| SCHEMBL7420258 | 0.77 | SLC5A1 (0.55) | PDE4BPDE4DSLC5A1SLC5A2MEN1 | |
| SCHEMBL4522214 | 0.76 | PDE4B (0.67) | PDE4BPDE4DSLC5A1SLC5A2MEN1 | |
| SCHEMBL31117214 | 0.76 | MAPT (0.76) | PDE4BPDE4DSLC5A1SLC5A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248781-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2002-10-16 | — | — | EP | claimed |
| WO-2001046172-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2001-06-28 | — | — | WO | claimed |
| EP-1248781-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001046172-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2001-06-28 | — | — | WO | disclosed |