Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 1/20 | 0.55 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070168 | 0.83 | PDE4B (0.67) | SLC5A1SLC5A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7472993 | 0.83 | PKM (0.56) | SLC5A1SLC5A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7470365 | 0.80 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2GAAMAPTMAPK1 | |
| SCHEMBL7473041 | 0.77 | PDE4B (0.72) | SLC5A1SLC5A2SMN1; SMN2MAPTNPC1 | |
| SCHEMBL7471831 | 0.77 | PDE4D (0.66) | ALDH1A1SMN1; SMN2GAAMAPTNPC1 | |
| SCHEMBL11082376 | 0.76 | SLC5A1 (0.55) | SLC5A1SLC5A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL29444927 | 0.75 | SLC5A1 (0.48) | SLC5A1SLC5A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL11283595 | 0.74 | MAPT (0.47) | ALDH1A1SMN1; SMN2GAAMAPTMAPK1 | |
| SCHEMBL12165819 | 0.73 | SLC5A1 (0.48) | SLC5A1SLC5A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL2557420 | 0.73 | MAPT (0.49) | SLC5A1SLC5A2ALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248781-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2002-10-16 | — | — | EP | claimed |
| WO-2001046172-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2001-06-28 | — | — | WO | claimed |
| EP-1248781-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001046172-A1 | PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS | ICOS CORPORATION (US) | 2001-06-28 | — | — | WO | disclosed |