Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 8/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 8/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472274 | 0.93 | KCNE1 (0.53) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL8481443 | 0.90 | KCNE1 (0.49) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL7471057 | 0.87 | KCNE1 (0.46) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL7466032 | 0.86 | KCNE1 (0.48) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL8479947 | 0.86 | KCNE1 (0.52) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6602327 | 0.86 | KCNE1 (0.48) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6601925 | 0.85 | KCNE1 (0.44) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL8482616 | 0.85 | KCNE1 (0.49) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6604472 | 0.84 | KCNE1 (0.45) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6600267 | 0.83 | KCNE1 (0.48) | KCNE1KCNQ1KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |