Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 8/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 8/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600267 | 0.93 | KCNE1 (0.48) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6601925 | 0.89 | KCNE1 (0.44) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6600854 | 0.89 | KCNE1 (0.46) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6600820 | 0.88 | KCNE1 (0.47) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL7910176 | 0.88 | KCNE1 (0.47) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL7472274 | 0.87 | KCNE1 (0.53) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6602717 | 0.87 | KCNE1 (0.43) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6603010 | 0.86 | CNR2 (0.43) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL7473047 | 0.86 | KCNE1 (0.50) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL7900354 | 0.86 | KCNE1 (0.46) | KCNE1KCNQ1KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906911-B1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6177449-B1 | CARDIOVASCULAR DISORDERS; ANTIULCER AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-23 | — | — | US | disclosed |
| EP-0906911-A1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-07 | — | — | EP | disclosed |