Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473523 | 1.00 | CES2 (0.42) | CES2CES1DPP4PPARGMRGPRX4 | |
| SCHEMBL7466214 | 0.86 | CES2 (0.42) | CES2CES1DPP4PPARGMRGPRX4 | |
| SCHEMBL29010121 | 0.84 | DPP4 (0.42) | CES2CES1DPP4PPARGMRGPRX4 | |
| SCHEMBL6681459 | 0.83 | CES2 (0.51) | CES2CES1 | |
| SCHEMBL6702844 | 0.83 | CES2 (0.51) | CES2CES1 | |
| SCHEMBL6681467 | 0.83 | CES2 (0.51) | CES2CES1 | |
| SCHEMBL19183089 | 0.81 | AKR1C3 (0.46) | DPP4PPARGEPHX2AKR1C3AKR1C2 | |
| SCHEMBL3620551 | 0.81 | DPP4 (0.48) | DPP4PPARGMRGPRX4SLC6A4SLC6A2 | |
| SCHEMBL11846885 | 0.79 | RXRA (0.44) | EPHX2AKR1C3AKR1C2 | |
| SCHEMBL7680267 | 0.79 | DPP4 (0.41) | DPP4PPARGMRGPRX4SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6358971-B1 | FOR INHIBITING THE GROWTH OF A PICORNAVIRUS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |