Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469321 | 0.89 | TSHR (0.58) | TSHRALDH1A1SMN1; SMN2MAPK1GSK3B | |
| SCHEMBL7467559 | 0.85 | TSHR (0.58) | TSHRALDH1A1SMN1; SMN2SIRT1TP53 | |
| SCHEMBL7471315 | 0.84 | ALDH1A1 (0.68) | TSHRALDH1A1SMN1; SMN2TP53HTT | |
| SCHEMBL7476860 | 0.84 | TSHR (0.64) | TSHRALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL7473291 | 0.83 | TSHR (0.54) | TSHRALDH1A1SMN1; SMN2TP53HTT | |
| SCHEMBL7472920 | 0.82 | TSHR (0.56) | TSHRALDH1A1SMN1; SMN2TP53HTT | |
| SCHEMBL7472497 | 0.81 | TSHR (0.47) | TSHRALDH1A1SMN1; SMN2TP53HTT | |
| SCHEMBL8348428 | 0.80 | TSHR (0.52) | TSHRALDH1A1SMN1; SMN2SIRT1TP53 | |
| SCHEMBL7472305 | 0.79 | TSHR (0.53) | TSHRALDH1A1SMN1; SMN2TP53HTT | |
| SCHEMBL7476998 | 0.78 | TSHR (0.52) | TSHRALDH1A1SMN1; SMN2HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869949-B1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO MCNEIL PHARM INC (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-0869949-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997017333-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |