Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LTA4H | P09960 | 5/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046871 | 0.90 | MEN1 (0.54) | PPIDMEN1KMT2ALTA4HNR1H4 | |
| SCHEMBL75205 | 0.79 | PPID (0.69) | PPIDSMN1; SMN2LTA4HALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3926946 | 0.78 | PPID (0.68) | PPIDSMN1; SMN2LTA4HALDH1A1MAPT | |
| SCHEMBL2834704 | 0.77 | ALDH1A1 (0.48) | PPIDMEN1KMT2ASMN1; SMN2LTA4H | |
| SCHEMBL4046878 | 0.74 | TP53 (0.40) | PPIDMEN1KMT2ASMN1; SMN2LTA4H | |
| SCHEMBL19796001 | 0.73 | ALDH1A1 (0.42) | PPIDMEN1KMT2ASMN1; SMN2LTA4H | |
| SCHEMBL12559711 | 0.73 | PPID (0.64) | PPIDMEN1KMT2ASMN1; SMN2LTA4H | |
| SCHEMBL12894961 | 0.72 | PPID (0.58) | PPIDMEN1KMT2ASMN1; SMN2LTA4H | |
| SCHEMBL10861409 | 0.72 | KMT2A (0.55) | MEN1KMT2ASMN1; SMN2NR1H4ALDH1A1 | |
| SCHEMBL13898294 | 0.70 | MEN1 (0.48) | PPIDMEN1KMT2ASMN1; SMN2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-A4 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1183033-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071129-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-30 | — | — | WO | disclosed |