Sugi Predict

Sugi Predict / Compounds / Hydroxyamine

Hydroxyamine

Hydroxyamine

SCHEMBL7474026

CCn1nc(-c2ccccc2)c2c(N(Cc3cccnc3)S(=O)(=O)c3ccc(OC)cc3)c(C(=O)O)cnc21.NO

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MMP9 P14780 20/20 0.59
▸ MMP13 P45452 20/20 0.59
▸ MMP1 P03956 19/20 0.59
▸ ADAM17 P78536 18/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7010468 0.98 MMP9 (0.61) MMP9MMP13MMP1ADAM17
SCHEMBL7010509 0.90 MMP9 (0.69) MMP9MMP13MMP1ADAM17
SCHEMBL7012033 0.86 MMP9 (0.57) MMP9MMP13MMP1ADAM17
SCHEMBL6290530 0.81 MMP9 (0.86) MMP9MMP13MMP1ADAM17
SCHEMBL6289447 0.81 MMP9 (0.84) MMP9MMP13MMP1ADAM17
Hydroxyamine SCHEMBL7538525 0.81 MMP9 (0.67) MMP9MMP13MMP1ADAM17
Hydroxyamine SCHEMBL7473572 0.79 MMP9 (0.83) MMP9MMP13MMP1ADAM17
SCHEMBL7014447 0.79 MMP9 (0.69) MMP9MMP13MMP1ADAM17
SCHEMBL7010013 0.79 MMP9 (0.69) MMP9MMP13MMP1ADAM17
Hydroxyamine SCHEMBL7562870 0.79 MMP9 (0.68) MMP9MMP13MMP1ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1021413-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 2000-07-26 — — EP claimed
WO-1999018076-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1999-04-15 — — WO claimed