Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482445 | 0.92 | MAPT (0.63) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7477984 | 0.85 | MAPT (0.56) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7478572 | 0.83 | MAPT (0.57) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7476548 | 0.83 | MAPT (0.54) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7476148 | 0.81 | MAPT (0.61) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7482437 | 0.81 | MAPT (0.53) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7477997 | 0.80 | MAPT (0.60) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7480875 | 0.79 | MAPT (0.58) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7478240 | 0.77 | MAPT (0.51) | MAPTTP53RAB9ANPC1MEN1 | |
| SCHEMBL7483976 | 0.77 | MAPT (0.53) | MAPTTP53RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |