Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | PPIA | P62937 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482437 | 0.90 | MAPT (0.53) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL7482445 | 0.84 | MAPT (0.63) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL7474057 | 0.77 | MAPT (0.61) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL7477984 | 0.77 | MAPT (0.56) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL7478543 | 0.76 | NPC1 (0.52) | MAPTRAB9ANPC1SMN1; SMN2NPSR1 | |
| SCHEMBL7476548 | 0.75 | MAPT (0.54) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL7478572 | 0.74 | MAPT (0.57) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2434317 | 0.70 | CASR (0.81) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL7480839 | 0.70 | GLS (0.55) | MAPTRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL4124085 | 0.70 | MAPT (0.81) | MAPTRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |