SCHEMBL7474070

SCHEMBL7474070

CC1CNC[C@H](C)N1c1nccnc1OCCOc1cccnc1

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 9/20 0.44
CHRNA4 P43681 9/20 0.44
CHRNA3 P32297 4/20 0.41
CHRNB4 P30926 3/20 0.41
CYP3A4 P08684 1/20 0.41
CHRNA7 P36544 3/20 0.40
CHRNA1 P02708 2/20 0.40
CHRNB1 P11230 2/20 0.40
CHRNG P07510 1/20 0.40
CHRND Q07001 1/20 0.40
CHRNB3 Q05901 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4320521 1.00 CHRNB2 (0.44) CHRNB2CHRNA4CHRNA3CHRNB4CYP3A4
SCHEMBL4320526 1.00 CHRNB2 (0.44) CHRNB2CHRNA4CHRNA3CHRNB4CYP3A4
SCHEMBL235730 0.85 CHRNA7 (0.44) CHRNB2CHRNA4CHRNA7
SCHEMBL2641453 0.85 CHRNA7 (0.44) CHRNB2CHRNA4CHRNA7
SCHEMBL4316440 0.85 CHRNA7 (0.44) CHRNB2CHRNA4CHRNA7
Hydrochloric Acid SCHEMBL29369063 0.85 CHRNA7 (0.45) CHRNB2CHRNA4CHRNA7
SCHEMBL15307685 0.78 CHRNB2 (0.49) CHRNB2CHRNA4CHRNA3CHRNB4CYP3A4
SCHEMBL4320113 0.78 CHRNB2 (0.48) CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7
SCHEMBL4308561 0.77 CHRNA7 (0.47) CHRNA7
SCHEMBL7465003 0.76 HRH4 (0.54) CHRNB2CHRNA4CHRNA3CHRNB4CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1178973-A2 NOVEL COMPOUNDS, THEIR USE AND PREPARATION Pharmacia AB (SE) 2002-02-13 EP disclosed
WO-2000076984-A2 NOVEL COMPOUNDS, THEIR USE AND PREPARATION BIOVITRUM AB (SE) 2000-12-21 WO disclosed