Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 4/20 | 0.42 |
| ▸ | MGAM | O43451 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | SI | P14410 | 3/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.41 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585185 | 0.86 | HPSE (0.44) | PARP1HPSEMGAMGAASI | |
| SCHEMBL6585182 | 0.85 | PARP1 (0.47) | PARP1HPSEPKN1PKN2 | |
| SCHEMBL6804373 | 0.84 | PARP1 (0.58) | PARP1PKN1PKN2PRKD3MAP4K4 | |
| SCHEMBL7484761 | 0.82 | HPSE (0.43) | PARP1HPSEMGAMGAASI | |
| SCHEMBL6591471 | 0.79 | PKN1 (0.56) | PARP1HPSEMGAMGAASI | |
| SCHEMBL7820437 | 0.77 | MMP13 (0.51) | PARP1GAAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4604974 | 0.77 | PARP1 (0.46) | PARP1GAAKDM4EHPGDRAB9A | |
| SCHEMBL7815539 | 0.77 | PARP1 (0.57) | PARP1HPSEGAATP53KDM4E | |
| SCHEMBL6585180 | 0.76 | DHODH (0.63) | PARP1 | |
| SCHEMBL6581316 | 0.76 | MAP4K4 (0.55) | PARP1PKN2MAP4K4PIM1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |