Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 6/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.37 |
| ▸ | AVPR1B | P47901 | 5/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963072 | 0.93 | ADRA1D (0.33) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7953703 | 0.92 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7474383 | 0.89 | ADRA1D (0.34) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7955157 | 0.87 | AVPR2 (0.36) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7971950 | 0.86 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7474389 | 0.85 | AVPR2 (0.33) | AVPR2AVPR1ATSHRTLR9TLR7 | |
| SCHEMBL7474244 | 0.85 | AVPR2 (0.33) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7342173 | 0.83 | AVPR2 (0.43) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7338105 | 0.83 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7342320 | 0.82 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |