Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 5/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955154 | 0.93 | ADRA1D (0.32) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7953703 | 0.91 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7971950 | 0.88 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7474378 | 0.87 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7962662 | 0.84 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7479773 | 0.84 | AVPR2 (0.32) | AVPR2AVPR1AEPHX2MEN1POLB | |
| Hydrochloric Acid SCHEMBL7954106 | 0.84 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7964892 | 0.84 | AVPR2 (0.35) | AVPR2AVPR1AAVPR1BMEN1KMT2A | |
| SCHEMBL7474244 | 0.84 | AVPR2 (0.33) | AVPR2AVPR1AAVPR1BADRA1DADRA1A | |
| SCHEMBL7973515 | 0.83 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BEPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |