Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | EDNRA | P25101 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420612 | 0.95 | ALDH1A1 (0.44) | MEN1KMT2ARXFP1SLC22A12SMN1; SMN2 | |
| SCHEMBL7473906 | 0.89 | ALDH1A1 (0.43) | SLC22A12SMN1; SMN2TSHRALDH1A1KDM4E | |
| SCHEMBL7476678 | 0.88 | SLC22A12 (0.39) | SLC22A12SMN1; SMN2TSHRALDH1A1KDM4E | |
| SCHEMBL7470778 | 0.85 | DPP4 (0.46) | MEN1KMT2ARXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7426960 | 0.83 | ALDH1A1 (0.51) | SLC22A12SMN1; SMN2TSHRALDH1A1KDM4E | |
| SCHEMBL7421878 | 0.82 | KDM4E (0.41) | SLC22A12SMN1; SMN2TSHRALDH1A1KDM4E | |
| SCHEMBL7371677 | 0.80 | ALDH1A1 (0.45) | RXFP1SMN1; SMN2TSHRALDH1A1KDM4E | |
| SCHEMBL7422984 | 0.79 | DPP4 (0.47) | MEN1KMT2ARXFP1TSHRALDH1A1 | |
| SCHEMBL7423537 | 0.76 | MEN1 (0.40) | MEN1KMT2ARXFP1SLC22A12SMN1; SMN2 | |
| SCHEMBL7429126 | 0.74 | MEN1 (0.40) | MEN1KMT2ARXFP1SLC22A12SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |