Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422984 | 0.94 | DPP4 (0.47) | DPP4MAPTTP53LMNAMAPK1 | |
| SCHEMBL7424979 | 0.88 | FABP4 (0.51) | DPP4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL7467571 | 0.87 | DPP4 (0.44) | DPP4TP53LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL7473427 | 0.86 | DPP4 (0.46) | DPP4MAPTTP53LMNAMAPK1 | |
| SCHEMBL7474496 | 0.85 | MEN1 (0.43) | DPP4MAPTLMNAMAPK1L3MBTL1 | |
| SCHEMBL7371677 | 0.83 | ALDH1A1 (0.45) | DPP4MAPTTP53LMNAMAPK1 | |
| SCHEMBL7474547 | 0.82 | HDAC1 (0.52) | DPP4MAPTTP53LMNAMAPK1 | |
| SCHEMBL7416251 | 0.82 | ALDH1A1 (0.54) | DPP4MAPTTP53LMNAMAPK1 | |
| SCHEMBL7423051 | 0.81 | DPP4 (0.45) | DPP4MAPTTP53LMNAMAPK1 | |
| SCHEMBL7420612 | 0.79 | ALDH1A1 (0.44) | DPP4MAPTLMNAMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |