Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.64 |
| ▸ | GLA | P06280 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2584410 | 0.93 | ALDH1A1 (0.65) | RAB9ANPC1ALDH1A1ALOX12GLA | |
| SCHEMBL23068125 | 0.86 | NPC1 (0.62) | RAB9ANPC1ALDH1A1ALOX12GLA | |
| SCHEMBL4522241 | 0.85 | SMN1; SMN2 (0.76) | RAB9ANPC1ALDH1A1SMN1; SMN2EPHX1 | |
| SCHEMBL25123079 | 0.85 | SMN1; SMN2 (0.76) | RAB9ANPC1ALDH1A1SMN1; SMN2EPHX1 | |
| SCHEMBL8395225 | 0.85 | SMN1; SMN2 (0.76) | RAB9ANPC1ALDH1A1SMN1; SMN2EPHX1 | |
| SCHEMBL5123025 | 0.84 | NPC1 (0.60) | RAB9ANPC1ALDH1A1ALOX12GLA | |
| SCHEMBL7993458 | 0.84 | ALDH1A1 (0.56) | RAB9ANPC1ALDH1A1ALOX12GLA | |
| SCHEMBL8391563 | 0.83 | SMN1; SMN2 (0.73) | NPC1SMN1; SMN2EPHX1MEN1KMT2A | |
| Methyl Alcohol SCHEMBL11518093 | 0.82 | SMN1; SMN2 (0.72) | SMN1; SMN2EPHX1MEN1KMT2AKDM4E | |
| SCHEMBL9938762 | 0.81 | SMN1; SMN2 (0.66) | RAB9AALDH1A1SMN1; SMN2EPHX1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194421-A4 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1194421-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001002379-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |